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In univariate analyses, increased postoperative complications were observed among patients in the ileal pouch cohort who received anti-TNF agents preoperatively vs those who did not (137 [45.2%] vs 327 [37.6%]; P = .02) but not among those in the colectomy or proctocolectomy cohorts. The Truven Medicare database contains the healthcare experience of individuals with Medicare supplemental insurance paid for by employers. Specifically, we discuss six main endophenotype hypotheses in AD: amyloidosis, tauopathy, neuroinflammation, mitochondrial dysfunction, vascular dysfunction, and lysosomal dysfunction. There were no differences in annual healthcare utilization for CCHC of mothers with and without depressive symptoms. MarketScan Ⓡ MarketScan Ⓡ Inpatient View; Diagnosis/Procedure Query; Link View Query; MarketScan Ⓡ Outpatient View; Diagnosis/Procedure Query; Admin; User List; User Activity Report; Expiration Report The Truven Health MarketScan® database was selected because it is considered the gold standard in proprietary US healthcare databases, containing real-world data for healthcare research and analytics. It consists of annual employer and health plan sourced medical and drug data on millions of individuals, including those covered by employer sponsored private health insurance, their spouses, and dependents. Reoperation was defined by ipsilateral knee procedure after the index … ), cost for 5 years of data with roughly 500,000 unique patients with specific ICD-9 codes was $25K. Sixty-eight percent of the patients had treatment disruptions and 34% discontinued cetuximab treatment. One strength of using administrative databases in evaluating pregnancy outcomes includes the possibility of accruing large numbers of exposures and pregnancy outcomes, particularly when multiple databases are combined. Of 25 481 patients who underwent colectomy, 4160 were included in the study (laparoscopic, 45.6%; open, 54.4%). The consistency observed between the key findings of the retrospective claims analysis and the registry regarding pregnancy outcomes in the setting of sumatriptan exposure supports the feasibility of retrospective observational study approaches in evaluating post‐approval safety of triptan exposure in pregnancy. The MarketScan Medicare Supplemental and Coordination of Benefits Database is a research database owned by Truven Health Analytics. Data were collected and analyzed from February 1, 2015, to June 2, 2016. We described a novel approach to summarize clinical manifestations from patient EHRs into phenotypic evidence for cystic fibrosis (CF) with potential to alert unrecognized patients of the disease. There were 40 063 patients identified, with a total of 420 773 cycles [remission (197 111; 46.8%), mild-moderate (44 024; 10.5%), moderate-severe (132 695; 31.5%), severe-fulminant (46 925; 11.2%)]. Using the 2010-2014 MarketScan Commercial Claims and Encounters database, this analysis identified the percentage of patients (N=36,719) with an opioidrelated inpatient admission who - received substance use disorder treatment medications within 30 days of being discharged. There were no recorded stillbirths or major birth defects for first‐trimester naratriptan exposures in the claims analysis. Assessing Treatment-Related Toxicity Using Administrative Data, Patient-Reported Outcomes, or Physician-Graded Toxicity: Where Is the Truth? The total cost for outpatient GI endoscopy examinations was $32.4 billion. However, the effect of increasing use of laparoscopy on overall health care utilization and costs, especially in the long term, has not been thoroughly investigated. We collected information on the epidemiology of GI diseases (including cancers) and symptoms, along with data on resource utilization, quality of life, impairments to work and activity, morbidity, and mortality. Following two decades of more than 400 clinical trials centered on the “one drug, one target, one disease” paradigm, there is still no effective disease‐modifying therapy for Alzheimer's disease (AD). The data come from a selection of large employers, health plans, and government and public organizations. States: 2014. Background In contrast, the number of exposed pregnancies included in the final analysis of the registry was 617 for sumatriptan, 57 for naratriptan, and 6 for sumatriptan/naproxen sodium, and the majority of exposed pregnancies also had triptan exposure during the first trimester (Table 1). Hence, individuals included in the database are covered under private insurance plans; no Medicaid or … The distribution of major cardiometabolic diseases in the CEMR is comparable with the national survey results. Abbreviation: NSAID, nonsteroidal anti‐inflammatory drugs. Metformin exposure was assessed by prescription tracking within the 12-month period before the index date. These claims data are collected from several hundred insurance providers, … In addition, the prescription database lacks information on medication dispensed during hospital admissions or obtained from the doctor's office as samples. The MarketScan databases are a family of administrative claims databases that contain data on inpatient and outpatient claims, outpatient prescription claims, clinical utilization records, and healthcare expenditures. About 5120 pregnancies were identified in the retrospective claims cohort in contrast to 617 included in the prospective registry during the same time frame. Physician-graded toxicity is a relatively more objective measure, but relies on both clinicians fully assessing all relevant symptoms and patients accurately reporting them to the clinician. In this analysis, we assembled cohorts of pregnant women with migraine exposed to 1 of 3 triptans during pregnancy using an insurance administrative claims database and assessed pregnancy outcomes and proportion of major birth defects among live‐born infants linkable to their birth mothers. Truven, and to a lesser extent Symphony, do not capture all Medicare and Medicaid enrollees. Crohn's disease is a chronic condition that often presents in early adulthood. IBM® MarketScan® Research Databases provide one of the longest-running and largest collections of proprietary de-identified claims data for privately and publicly insured people in the US. In patients with active PsA, tofacitinib had a safety profile that was generally consistent with patients with PsA receiving other therapies in real … Methods: Data between 1 January 2006 and 31 December 2014 from patients aged 6-17 years in the Truven Health Analytics MarketScan database were used to generate two cohorts of patients: (1) atomoxetine users and (2) stimulant (methylphenidates or amphetamines) users. Metformin use appears to be associated with a reduced risk of developing CRC among diabetic patients in the United States. For information please submit a CEDAR SPARC request or contact Dr. Triptan exposure in pregnant migraine patients therefore offers a good example to examine whether assessment of safety using existing databases can provide findings comparable to those from a prospective pregnancy registry. In primary care, only ultrasound is more frequently ordered in those <65 years. Overall, there was broad agreement between the findings of the claims analysis and the registry. To draw meaningful inferences from such studies, it is essential to fully understand the characteristics of the underlying population and potential biases in EMRs. Materials and Methods Acute pancreatitis was the most common reason for hospitalization (274,119 discharges). The MarketScan Commercial Claims and Encounters Database is a research database owned by Truven Health Analytics. The CEMR represents the general US population well in terms of office visits and major chronic conditions, whereas the potential subgroup differences in terms of age and gender distribution and prevalence may differ and, therefore, should be carefully taken care of in future studies. The Truven Health Marketscan® ... MarketScan® database represent the amount eligible for payment to providers after applying pricing guidelines such as fee schedules and discounts, and before applying deductibles, copayments, and coordination of benefits. We used data from the Truven Health MarketScan Commercial Claims and Encounter Database and the Medicare Supplemental and Coordination of Benefits Database (Truven Health Analytics, Ann Arbor, Michigan) for the period of January 1, 2009 through June 30, 2015. 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